|Efficiency of cannabinoids against cancer|
Endocannabinoids and cannabinoids are also found at the intersection of the body's various systems, allowing communication and coordination between different cell types. At the site of an injury, for example, cannabinoids can be found decreasing the release of activators and sensitisers from the injured tissue, stabilising the nerve cell to prevent excessive firing, and calming nearby immune cells to prevent release of pro-inflammatory substances. Three different mechanisms of action on three different cell types for a single purpose: minimise the pain and damage caused by the injury.
|A neurotransmitter called anandamide was isolated in chocolate by neuroscientist Daniel Piomelli in 1996|
Endocannabinoids are the substances our bodies naturally make to stimulate these receptors. The two most well understood of these molecules are called anandamide and 2-arachidonoylglycerol (2-AG). They are synthesised on-demand from cell membrane arachidonic acid derivatives (important family of regulatory molecules), have a local effect and short half-life before being degraded.
Phytocannabinoids are plant substances that stimulate cannabinoid receptors. Delta-9-tetrahydrocannabinol, or THC, is the most psychoactive and certainly the most famous of these substances, but other cannabinoids such as cannabidiol (CBD) and cannabinol (CBN) are gaining the interest of researchers due to a variety of healing properties. Most phytocannabinoids have been isolated from Cannabis sativa L., but other medical herbs, such as Echinacea purpura, have been found to contain non-psychoactive cannabinoids as well.
|Ancient Tibetan medicine|